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1

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach

Krackhardt, Angela M., Anliker, Brigitte, Hildebrandt, Martin, Bachmann, Michael, Eichmüller, Stefan B., Nettelbeck, Dirk M., Renner, Matthias, Uharek, Lutz, Willimsky, Gerald, Schmitt, Michael, Wels,

Journal:

Cancer Immunology, Immunotherapy

Year:

2018

Language:

english

File:

PDF, 944 KB

english, 2018

2

On the heading stability of a ship in waves

Cura-Hochbaum, Andrés, Uharek, Sebastian

Journal:

Ship Technology Research

Year:

2019

Language:

english

File:

PDF, 1.44 MB

english, 2019

3

Epithelial barrier dysfunction as permissive pathomechanism in human intestinal graft-versus-host disease

Troeger, Hanno, Hering, Nina A., Bojarski, Christian, Fromm, Anja, Barmeyer, Christian, Uharek, Lutz, Siegmund, Britta, Fromm, Michael, Rieger, Kathrin, Schulzke, Jörg-Dieter

Journal:

Bone Marrow Transplantation

Year:

2018

Language:

english

File:

PDF, 907 KB

english, 2018

4

Cellular composition, antileukemic activity and hematopoletic potential of peripheral blood progenitor cell (PBPC) grafts mobilized by G-CSF and SCF

G. Hartung, L. Uharek, M. Zeis, B. Glass, N. Schmitz, M. Krönke, J. Steinmann

Journal:

Immunology Letters

Year:

1997

Language:

english

File:

PDF, 190 KB

english, 1997

5

Graft-versus-leukaemia activity can be predicted by natural cytotoxicity against leukaemia cells

Bertram Glass, Lutz Uharek, Matthias Zeis, Helmut Loeffler, Wolfgang Mueller-Ruchholtz, Winifried Gassmann

Journal:

British Journal of Haematology

Year:

1996

Language:

english

File:

PDF, 144 KB

english, 1996

6

Allogeneic MHC-mismatched activated natural killer cells administered after bone marrow transplantation provide a strong graft-versus-leukaemia effect in mice

M. Zeis, L. Uharek, B. Glass, J. Steinmann, P. Dreger, W. Gassmann, N. Schmitz

Journal:

British Journal of Haematology

Year:

1997

Language:

english

File:

PDF, 498 KB

english, 1997

7

Activation of natural killer cells with interleukin 2 (IL-2) and IL-12 increases perforin binding and subsequent lysis of tumour cells

Christof Lehmann, Matthias Zeis, Lutz Uharek

Journal:

British Journal of Haematology

Year:

2001

Language:

english

File:

PDF, 643 KB

english, 2001

8

Enhanced antitumoral effectiveness of idiotype vaccination induced by the administration of Flt3 ligand combined with interleukin 2 against a murine myeloma

Matthias Zeis, Tim Zunkel, Jörg Steinmann, Norbert Schmitz, Lutz Uharek

Journal:

British Journal of Haematology

Year:

2002

Language:

english

File:

PDF, 275 KB

english, 2002

9

Therapeutic effects of idiotype vaccination can be enhanced by the combination of granulocyte–macrophage colony-stimulating factor and interleukin 2 in a myeloma model

Jan Stritzke, Tim Zunkel, Jörg Steinmann, Norbert Schmitz, Lutz Uharek, Matthias Zeis

Journal:

British Journal of Haematology

Year:

2003

Language:

english

File:

PDF, 350 KB

english, 2003

10

Gaft-versus-leukemia activity after bone marrow transplantation does not require graft-versus-host disease

B. Glass, L. Uharek, W. Gassmann, B. Focks, H. Bolouri, H. Loeffler, W. Mueller-Ruchholtz

Journal:

Annals of Hematology

Year:

1992

Language:

english

File:

PDF, 546 KB

english, 1992

11

Investigating the lysis of small-cell lung cancer cell lines by activated natural killer (NK) cells with a fluorometric assay for NK-cell-mediated cytotoxicity

C. Lehmann, B. Glass, M. Zeis, N. Schmitz, L. Uharek

Journal:

Cancer Immunology, Immunotherapy

Year:

1999

Language:

english

File:

PDF, 159 KB

english, 1999

12

Intrathecal application of donor lymphocytes in leukemic meningeosis after allogeneic stem cell transplantation

Martin Neumann, Igor W. Blau, Thomas Burmeister, Carola Tietze-Buerger, Olga Blau, Armin Gerbitz, Lutz Uharek, Eckhard Thiel

Journal:

Annals of Hematology

Year:

2011

Language:

english

File:

PDF, 216 KB

english, 2011

13

Biocompatible porous ceramics for the cultivation of hematopoietic cells

Almuth Berthold, Astrid Haibel, Natascha Brandes, Lothar Kroh, Ulrich Gross, Lutz Uharek, Helmut Schubert

Journal:

Journal of Materials Science: Materials in Medicine

Year:

2007

Language:

english

File:

PDF, 364 KB

english, 2007

14

Immune reconstitution and cytomegalovirus infection after allogeneic stem cell transplantation: the important impact of in vivo T cell depletion

Martin Schmidt-Hieber, S. Schwarck, A. Stroux, S. Ganepola, P. Reinke, E. Thiel, L. Uharek, I. W. Blau

Journal:

International Journal of Hematology

Year:

2010

Language:

english

File:

PDF, 282 KB

english, 2010

15

Air embolism simulating atypical pneumonia

Olaf Penack, Karl-Jürgen Wolf, Lutz Uharek

Journal:

British Journal of Haematology

Year:

2005

Language:

english

File:

PDF, 61 KB

english, 2005

16

Efficacy of the interleukin-2 receptor antagonist basiliximab in steroid-refractory acute graft-versus-host disease

Martin Schmidt-Hieber, Thomas Fietz, Wolfgang Knauf, Lutz Uharek, Werner Hopfenmüller, Eckhard Thiel, Igor Wolfgang Blau

Journal:

British Journal of Haematology

Year:

2005

Language:

english

File:

PDF, 92 KB

english, 2005

17

A new HLA-B52 allele, B52:23, detected in a patient before bone marrow transplantation

K. Todorova, H. Schulze, J. Ciroki, L. Uharek, A. Salama, C. Schönemann

Journal:

Tissue Antigens

Year:

2011

Language:

english

File:

PDF, 581 KB

english, 2011

18

Clinical-scale generation of human anti-Aspergillus T cells for adoptive immunotherapy

Tramsen, L, Koehl, U, Tonn, T, Latgé, J-P, Schuster, F R, Borkhardt, A, Uharek, L, Quaritsch, R, Beck, O, Seifried, E

Journal:

Bone Marrow Transplantation

Year:

2008

Language:

english

File:

PDF, 226 KB

english, 2008

19

Prophylactic i.v. Igs in patients with a high risk for CMV after allo-SCT

Schmidt-Hieber, M, Schwarck, S, Stroux, A, Thiel, E, Ganepola, S, Uharek, L, Blau, I W

Journal:

Bone Marrow Transplantation

Year:

2009

Language:

english

File:

PDF, 227 KB

english, 2009

20

Limited penetration of posaconazole into cerebrospinal fluid in an allogeneic stem cell recipient with invasive pulmonary aspergillosis

Reinwald, M, Uharek, L, Lampe, D, Grobosch, T, Thiel, E, Schwartz, S

Journal:

Bone Marrow Transplantation

Year:

2009

Language:

english

File:

PDF, 83 KB

english, 2009

21

Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery

Dreger, P, Viehmann, K, von Neuhoff, N, Glaubitz, T, Petzoldt, O, Glass, B, Uharek, L, Rautenberg, P, Suttorp, M, Mills, B

Journal:

Bone Marrow Transplantation

Year:

1999

Language:

english

File:

PDF, 102 KB

english, 1999

22

Transfer of idiotypic protein primed allogeneic marrow grafts elicits potent graft-versus-myeloma effects in mice

Zeis, M, Steinmann, J, Petrela, E, Hartung, G, Schmitz, N, Uharek, L

Journal:

Bone Marrow Transplantation

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

23

Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) in a murine transplantation model

Hartung, G, Zeis, M, Glass, B, Dreger, P, Steinmann, J, Schmitz, N, Uharek, L

Journal:

Bone Marrow Transplantation

Year:

2003

Language:

english

File:

PDF, 209 KB

english, 2003

24

Use of natural killer cells in hematopoetic stem cell transplantation

Passweg, J R, Stern, M, Koehl, U, Uharek, L, Tichelli, A

Journal:

Bone Marrow Transplantation

Year:

2005

Language:

english

File:

PDF, 132 KB

english, 2005

25

BCR-ABL transcripts are early predictors for hematological relapse in chronic myeloid leukemia after hematopoietic cell transplantation with reduced intensity conditioning

Lange, T, Deininger, M, Brand, R, Hegenbart, U, Al-Ali, H, Krahl, R, Poenisch, W, Uharek, L, Leiblein, S, Gentilini, C

Journal:

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

26

CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets

Penack, O, Gentilini, C, Fischer, L, Asemissen, A M, Scheibenbogen, C, Thiel, E, Uharek, L

Journal:

Year:

2005

Language:

english

File:

PDF, 167 KB

english, 2005

27

Reply to ‘NK cell subsets and CD107a mobilization assay’ by Zimmer et al

Penack, O, Gentilini, C, Fischer, L, Asemissen, A M, Scheibenbogen, C, Thiel, E, Uharek, L

Journal:

Year:

2005

Language:

english

File:

PDF, 53 KB

english, 2005

28

Reply to Dr Grzywacz

Penack, O, Uharek, L

Journal:

Year:

2007

Language:

english

File:

PDF, 77 KB

english, 2007

29

Intensified Strategies to Control Vancomycin-Resistant Enterococci in Immunocompromised Patients

M. Schmidt-Hieber, I. W. Blau, S. Schwartz, L. Uharek, K. Weist, T. Eckmanns, D. Jonas, H. Rüden, E. Thiel, C. Brandt

Journal:

International Journal of Hematology

Year:

2007

Language:

english

File:

PDF, 226 KB

english, 2007

30

A Novel Method to Quantify and Characterize Leukemia-Reactive Natural Killer Cells in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation following Conventional or Reduced-Dose Conditioning

Olaf Penack, Lars Fischer, Andrea Stroux, Chiara Gentilini, Axel Nogai, Arne Muessig, Susanne Ganepola, Thoralf Lange, Constanze Kliem, Olga Marinets, Igor Wolfgang Blau, Eckhard Thiel, Lutz Uharek

Journal:

International Journal of Hematology

Year:

2007

Language:

english

File:

PDF, 191 KB

english, 2007

31

Ifosfamide and ACNU in experimental allogeneic bone marrow transplantation

W. Gassmann, A. Erbersdobler, L. Uharek, B. Glass, H. Löffler, W. Mueller-Ruchholtz

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1991

Language:

english

File:

PDF, 407 KB

english, 1991

32

Allogeneic NK cells can eradicate leukemia after allogeneic bone marrow transplantation in mice

M. Zeis, L. Uharek, B. Glass, T. Gaska, J. Steinmann, W. Gassmann, H. Löffler, W. Mueller-Ruchholtz

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1995

Language:

english

File:

PDF, 143 KB

english, 1995

33

Human allogeneic NK-cells activated by IL-2 and IL-12 efficiently lyse fresh acute leukemia blasts

L. Uharek, M. Zeis, B. Glass, T. Gaska, J. Steinmann, W. Gassmann, H. Löffler, W. Mueller-Ruchholtz

Journal:

Journal of Cancer Research and Clinical Oncology

Year:

1995

Language:

english

File:

PDF, 112 KB

english, 1995

34

Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell lines

K. Frenzel, S. Ganepola, D. Michel, E. Thiel, D. H. Krüger, L. Uharek, J. Hofmann

Journal:

Medical Microbiology and Immunology

Year:

2012

Language:

english

File:

PDF, 443 KB

english, 2012

35

The anti-lymphoma effect of antibody-mediated immunotherapy is based on an increased degranulation of peripheral blood natural killer (NK) cells

Lars Fischer, Olaf Penack, Chiara Gentilini, Axel Nogai, Arne Muessig, Eckhard Thiel, Lutz Uharek

Journal:

Experimental Hematology

Year:

2006

Language:

english

File:

PDF, 296 KB

english, 2006

36

High-dose cytostatic agents in allogeneic bone marrow transplantation: comparison of the engraftment promoting potential

W. Gassmann, L. Uharek, A. Erbersdobler, B. Glass, H.-U. Wottge, N. Schmitz, H. Löffler, W. Mueller-Ruchholtz

Journal:

British Journal of Haematology

Year:

1991

Language:

english

File:

PDF, 1.08 MB

english, 1991

37

Influence of donor lymphocytes on the incidence of primary graft failure after allogeneic bone marrow transplatition in a murine model

Ltz Uharek, Bertram Glass, Winfried Gassmann, Helmut Loeffler, Wolfgang MuellerRchholtz

Journal:

British Journal of Haematology

Year:

1994

Language:

english

File:

PDF, 826 KB

english, 1994

38

Adoptive T-Cell Therapy of a Lung Transplanted Patient with Severe CMV Disease and Resistance to Antiviral Therapy

G. Brestrich, S. Zwinger, A. Fischer, M. Schmück, A. Röhmhild, M. H. Hammer, A. Kurtz, L. Uharek, C. Knosalla, H. Lehmkuhl, H.-D. Volk, P. Reinke

Journal:

American Journal of Transplantation

Year:

2009

Language:

english

File:

PDF, 330 KB

english, 2009

39

Detection of a novel HLA-A allele, designated A*02:334

H. Schulze, K. Todorova, J. Cirocki, L. Uharek, C. Schönemann

Journal:

Tissue Antigens

Year:

2012

Language:

english

File:

PDF, 516 KB

english, 2012

40

Allogeneic hematopoietic SCT in patients with AML following treosulfan/fludarabine conditioning

Casper, J, Holowiecki, J, Trenschel, R, Wandt, H, Schaefer-Eckart, K, Ruutu, T, Volin, L, Einsele, H, Stuhler, G, Uharek, L, Blau, I, Bornhaeuser, M, Zander, A R, Larsson, K, Markiewicz, M, Giebel, S,

Journal:

Bone Marrow Transplantation

Year:

2012

Language:

english

File:

PDF, 416 KB

english, 2012

41

Central nervous system infections in immunocompromised patients – update on diagnostics and therapy

Schmidt-Hieber, Martin, Zweigner, Janine, Uharek, Lutz, Blau, Igor W., Thiel, Eckhard

Journal:

Leukemia and Lymphoma

Year:

2009

Language:

english

File:

PDF, 264 KB

english, 2009

42

Human allogeneic NK-cells activated by IL-2 and IL-12 efficientyl lyse fresh acute leukemia blasts

B. Glass, M. Zeis, L. Uharek, T. Gaska, J. Steinmann, W. Gassmann, H. Löffler, W. Mueller-Ruchholtz

Journal:

European Journal of Cancer

Year:

1995

Language:

english

File:

PDF, 126 KB

english, 1995

43

Combining Azacitidine (Vidaza®, Aza) and Donor Lymphocyte Infusions (DLI) as First Salvage Treatment in Patients (PTS) With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndromes (MDS) Relapsing After Allogeneic Hematopoietic Stem Cell Transplantation (allo-SCT): Interim-Analysis From the Azarela-Trial (NCT-00795548)

T. Schroeder, A.G. Czibere, N. Kröger, U. Platzbecker, G. Bug, L. Uharek, T. Luft, I. Bruns, F. Zohren, C. Wolschke, R. Fenk, R. Haas, G. Kobbe

Journal:

Biology of Blood and Marrow Transplantation

Year:

2011

Language:

english

File:

PDF, 63 KB

english, 2011

44

The type of ATG matters — Natural killer cells are influenced differentially by Thymoglobulin, Lymphoglobulin and ATG-Fresenius

Olaf Penack, Lars Fischer, Chiara Gentilini, Axel Nogai, Arne Muessig, Kathrin Rieger, Susanne Ganepola, Eckhard Thiel, Lutz Uharek

Journal:

Transplant Immunology

Year:

2007

Language:

english

File:

PDF, 196 KB

english, 2007

45

Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia: long-term clinical and MRD results of the German CLL Study Group CLL3X trial

Dreger, P., Dohner, H., Ritgen, M., Bottcher, S., Busch, R., Dietrich, S., Bunjes, D., Cohen, S., Schubert, J., Hegenbart, U., Beelen, D., Zeis, M., Stadler, M., Hasenkamp, J., Uharek, L., Scheid, C.,

Journal:

Year:

2010

Language:

english

File:

PDF, 326 KB

english, 2010

46

Cytogenetic studies in acute leukemia patients relapsing after allogeneic stem cell transplantation

Martin Schmidt-Hieber, Igor W. Blau, Gregor Richter, Seval Türkmen, Christiane Bommer, Gundula Thiel, Heidemarie Neitzel, Andrea Stroux, Lutz Uharek, Eckhard Thiel, Olga Blau

Journal:

Cancer Genetics and Cytogenetics

Year:

2010

Language:

english

File:

PDF, 310 KB

english, 2010

47

Natural-killer-cell-based treatment in haematopoietic stem-cell transplantation

Jakob R. Passweg, Ulrike Koehl, Lutz Uharek, Sandrine Meyer-Monard, André Tichelli

Journal:

Best Practice & Research Clinical Haematology

Year:

2006

Language:

english

File:

PDF, 165 KB

english, 2006

48

Randomized, Double-Blind, Placebo-Controlled Trial of Oral Budesonide for Prophylaxis of Acute Intestinal Graft-Versus-Host Disease After Allogeneic Stem Cell Transplantation (PROGAST)

Renate Schmelz, Martin Bornhäuser, Johannes Schetelig, Alexander Kiani, Uwe Platzbecker, Uta Schwanebeck, Xina Graehlert, Lutz Uharek, Gustavo Baretton, Rainer Schwerdtfeger, Roland Greinwald, Ralph M

Journal:

Gastroenterology

Year:

2011

Language:

english

File:

PDF, 122 KB

english, 2011

49

P266 - Murine DSS colitis as model for exploring mesenchymal stem cell therapy in inflammatory bowel disease

K. Flöckner, S. Wiechmann, T. Dehne, M. Zeitz, L. Uharek, K. Rieger, J. Maul

Journal:

Journal of Crohn's and Colitis

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

50

Azacitidine and donor lymphocyte infusions as first salvage therapy for relapse of AML or MDS after allogeneic stem cell transplantation

Schroeder, T, Czibere, A, Platzbecker, U, Bug, G, Uharek, L, Luft, T, Giagounidis, A, Zohren, F, Bruns, I, Wolschke, C, Rieger, K, Fenk, R, Germing, U, Haas, R, Kröger, N, Kobbe, G

Journal:

Year:

2013

Language:

english

File:

PDF, 435 KB

english, 2013

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